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How Does Nitrazepam Work?

How Does Nitrazepam Work?
  • Insomnia is a sleep disorder that is linked to an imbalance of chemicals in the central nervous system, or CNS. More specifically, it is usually the result of abnormally low levels of a chemical called gamma-aminobutyric acid, or GABA. This chemical is responsible for calming down overexcited nerve cells in the brain.
  • When there are low levels of GABA in the brain, various conditions are likely to happen, such as restlessness, anxiety and insomnia. Nitrazepam sleeping pills, also sold under the brand name Mogadon, work by stimulating GABA receptors in the CNS and this increases the production of this calming chemical.
  • As a result, this medication increases total sleep time by reducing the time it takes to fall asleep as well as the number of times you wake up during the night. You can buy sleeping tablets from established online pharmacies and choose nitrazepam to effectively prevent sleepless nights.
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How Long Does It Take for Nitrazepam to Work?

This safe hypnotic medication is well absorbed and takes about 30 to 60 minutes to become effective. For this reason, it should be taken shortly before going to bed. It reaches its peak concentration levels in the bloodstream within 2 hours. If you forget to take a dose at bedtime, do not take this medication at any other time close to your next scheduled dosage. If you take it without having a full night's sleep, nitrazepam side effects, like drowsiness and dizziness, may occur during the day.

How Sleeping Tablets Work

How Long Does Nitrazepam Last?

  • Nitrazepam stays effective in the body for an average duration of 6 to 8 hours. Therefore, you should make sure that you are able to have 7 to 8 hours of uninterrupted sleep. This therapeutic can also be used as a premedication before a minor surgery, particularly in low doses.
  • If you use nitrazepam tablets as a premedication before a minor surgery, the dose is usually 5 mg (half a nitrazepam 10 mg tablet) administered the night before the procedure. This can be followed by 2.5 mg the next morning, before the operation.
  • In general, nitrazepam helps nervous patients feel less apprehensive before an operation. If you use this medication before a procedure, like an endoscopy or dental treatment, always tell the physician as this medicine can interact with some anaesthetics.
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How Well Does Nitrazepam Work?

A common question asked by most patients is what is nitrazepam like in terms of its functioning?' The simplest understanding of nitrazepam tablets are that they fast-acting sleeping pills that normally help a person with insomnia fall asleep, from the first night of use. In a sleep study, the tolerance and effectiveness of this medication was compared to another sleep aid called zopiclone, as well as inactive placebo pills. A total of 99 patients were involved in the study and they were required to have at least one of the following symptoms:

  • An inability to fall asleep within 45 minutes
  • At least two night-time awakenings, with difficulty resuming sleep
  • Less than 6 hours of sleep per night

The study lasted 4 weeks and patients were given a placebo, in the first week, to establish a baseline for their insomnia. During the next two weeks, they were given a nitrazepam dosage of 5 mg, zopiclone or a placebo, according to a randomised schedule. In the final week, all patients were given a placebo again to evaluate the withdrawal effects of the treatments.

The results of the study showed that both sleeping medications tested were superior to the placebo in terms of the following:

  • Reduced time to fall asleep
  • An increase in the number of hours spent sleeping
  • An improvement in the quality of sleep
  • A reduction in the occurrence of early-morning awakenings

The assessment of side effects, completed by physicians, showed no significant differences between the two sleeping medications and placebo. Furthermore, the occurrence of withdrawal symptoms in the final week of the study was no greater than the inactive placebo treatment.

The findings of this study affirmed both the safety and efficacy of nitrazepam as a sleep aid.

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How Long Does Nitrazepam Stay In Your System?

On average, the half-life of this medication is 26 hours. Therefore, it takes about 26 hours for half of the medication to be entirely eliminated from the body. The length of time nitrazepam stays in a person's body can, however, vary depending on certain factors. The table below contains the most influential factors that determine the length of time this therapeutic stays in the body:

Frequency of administration The process of removing the medication from the system will be influenced by the duration of treatment and the dosage level too. If a person only takes this nitrazepam once, they will clear it from their system much faster than a person who has been taking it on a daily basis.
Age As a person gets older, their metabolism generally becomes slower. Therefore, older people tend to eliminate this medication from the system at a slower rate.
The height and weight of a person The size of a person, especially their weight, can influence the rate at which nitrazepam is expelled from the body. Although not always the case, medications are generally metabolised slower in heavier people, so they tend to stay in the system for longer.
A person's genes A person's genetic profile can affect how the body metabolises a therapeutic. Genetics can influence the way a person responds to this medication and how it is processed in their digestive system.
Metabolism In general, a faster metabolism causes a person to remove a medication from the body more quickly than a slower metabolism. Lifestyle factors, such as diet and exercise, can also affect a person's metabolism, thereby affecting the rate of elimination of the medicine.
Liver and kidney function If a person has a problem with their liver or kidneys, they will usually take longer to remove this medication from their system.

In a healthy adult, it will take about 5 days for 97% of this medication to be completely removed from the body. At this stage, a negligible amount will be detectable. Insomnia can have a significant effect on a person's quality of life and overall well-being too. It often causes unpleasant daytime symptoms, like a lack of energy, depressed mood and memory problems.

If you are suffering with insomnia and this condition is causing distress, you can buy nitrazepam tablets today and regain restorative sleep for a healthy, balanced life.

Don't forget, at, as well as strong sleeping pills, you can also buy a wide selection of anxiety medication and painkillers without a doctor's prescription!




Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for

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