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Zopiclone

This is a sleeping tablet that is used to treat chronic insomnia. It is popularly known by the brand names Imovane and Zimovane, and contains both sedative hypnotic and relaxant properties which contribute to how effective it is for treating chronic insomnia.

It provides users with a calming effect and is sometimes used to treat anxiety associated with insomnia.
After reading about the effects and side-effects of this medication, along with the zopiclone dosage instructions below, customers can buy Zopiclone online (along with a wide range of other sleeping pills) without a prescription.

NOTE: the information on this website is not intended to replace advice from a doctor or qualified medical expert.

What is Zopiclone?

Zopiclone tablets typically come in two strengths; 3.75 mg and 7.5 mg. However, they are also now available in 10 mg tablets at some online pharmacies. Of the different strengths available in the UK, zopiclone 7.5 mg is the strength that is most commonly used for treating bad bouts of chronic insomnia.

Like various other popular prescription sleeping tablets, zopiclone comes from a class of medication called nonbenzodiazepines. Nonbenzodiazepine sleep medicines are much newer than their benzodiazepine cousin and are also commonly referred to as Z drugs or Z hypnotics.

While benzodiazepines can produce a calming effect and help make patients feel sleepy, they can also be used to treat a host of other disorders. Nonbenzodiazepine medications on the other hand are generally only used for the treatment of insomnia and severe anxiety that is preventing patients from getting a good night's sleep.

Studies show that this medication can cure insomnia and improve sleep pattern over a short time by providing undisturbed rest.

What is Zopiclone?

How Zopiclone Tablets Work

While non-benzodiazepine hypnotic sleep medicine has a slightly different chemical structure than benzodiazepine sleep medicine, they both work in a similar way, acting on the brain to aid sleep.

The brain contains a natural chemical called gamma-aminobutyric acid or aminobutyric acid (GABA). GABA is a naturally occurring inhibitory neurotransmitter which blocks signals in the brain to help promote a calming feeling in the human body.

As well as promoting a calming feeling, GABA sends signals that help relax muscles and induce sleepiness.

This cyclopyrrolone hypnotic medication is known to work with the naturally occurring gamma-aminobutyric acid (GABA) in the body to quickly promote a feeling of calm and relaxation which make patients feel sleepy.

By promoting an increased feeling of relaxation, patients are able to fall asleep much quicker than they normally would.

While nonbenzodiazepines and benzodiazepines both act on the brain in a similar way, nonbenzodiazepines are considered a safer option for insomnia treatment, especially in patients over the age of 65 years old.

Because nonbenzodiazepine medication has a shorter half-life than benzodiazepines, the medication leaves the body quicker, and there is a decreased risk of patients experiencing daytime drowsiness the next day.

How Zopiclone Tablets Work
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Insomnia, Anxiety & Zopiclone Tablets

Everyone experiences difficulty sleeping from time to time, and up to 1/3 of the UK population is thought to be suffering from chronic insomnia. Insomnia is the regular occurrence of sleeping problems. If you regularly find it hard to get to sleep, lie awake at night, feel tired when you wake up or take naps during the day, then you have insomnia.

Depression along with anxiety are leading causes of insomnia, in fact they are kind of a package deal that create a vicious circle:

People that suffer from insomnia are more likely to suffer from anxiety, people with depression are more likely to suffer with insomnia, and people with anxiety disorders are more likely to lie awake at night thinking negative thoughts.

As such, while the main use of this medication is the treatment of insomnia it has been known for people to use zopiclone for anxiety also.

Zopiclone for Insomnia: Insomnia is a condition that is experienced by many individuals. It consists of two major types - one being the inability to fall asleep (sleep onset insomnia) and the other is having difficulty staying asleep.

Poor sleep can cause a multitude of issues including fatigue and depression. Luckily, this condition can be treated with a number of medications.

Most users report a noticeable reduction in the time it takes to get to sleep, as well as improved sleep quality.
Zopiclone for Anxiety: Some people use zopiclone for anxiety. The use of zopiclone for anxiety has been highly successful with an increasing number of patients experiencing positive results, thanks to the mild muscle relaxant properties. This medication provides a fast-acting calm, sleep-inducing effect which enables patients to relax and fall asleep.

Benzodiazepines vs Non-Benzodiazepines

  • The pharmacodynamics of non-benzodiazepines is similar to that of benzodiazepines thus making these classes of therapeutics closely related in benefits, adverse effects and hazards. However, this class of medications were synthesised in an attempt to optimise the pharmacodynamic and pharmacokinetic properties of benzodiazepines.
  • Non-benzodiazepines have dissimilar chemical structures to benzodiazepines, and are unrelated on a biochemical level, which could be a reason for the improved efficacies of these sleep aids.
  • Central nervous system (CNS) depression is potentiated by benzodiazepines. This is not likely with non-benzodiazepines, unless consumed with alcohol. This and other precautions can be found on our website when you buy zopiclone online.
  • There is little dependence concerns with zopiclone and tolerance is unlikely. This is because, when used for chronic conditions, zopiclone causes less receptor adaptation - which is owed to its characteristic interaction with the GABA receptor.
  • Different benzodiazepines have different abuse potential but in general, this class of medication still carry an increased risk of misuse over non-benzodiazepines.
  • Non-benzodiazepines are much more selective than the older benzodiazepines and are thus more precise.

What The Research Says:

  • Both classes of medications work by raising GABA activity. A meta-analysis of the comparison between benzodiazepines and non-benzodiazepines found zopiclone tablets were associated with fewer awakenings, increased total sleep time and better sleep quality. It was also revealed that patients found it simpler to fall asleep using zopiclone than benzodiazepines. 
  • Research shows that zopiclone, being a cyclopyrrolone, is superior and at very least equal to benzodiazepines (Montplaisir et al., 2003).
  • At normal dosages, Olsen (2008) reported that zopiclone caused impairment to cognition on a much smaller scale than benzodiazepines. Randomised controlled trials also revealed that adverse effects are lesser in severity and frequency for benzodiazepines than Z-drugs.
  • There is at least a 50% less chance of hip fractures in the elderly when using non-benzodiazepines. This was especially significant with continuous use or within the initial stages of administration.

How To Use Zopiclone 7.5 mg

It is recommended that patients carefully read and understand the usage instructions to fully benefit from this sleep medicine.

Zopiclone 7.5 mg should only be taken if you are certain that you are going to get a full 7 to 8 hours of sleep and at least 15 hours before needing to drive or operate machinery.

If you awaken before 7 - 8 hours, you may experience feelings of drowsiness, dizziness and decreased alertness.


Other usage guidelines recommended are as follows:

  • This medication can be taken with or without food, however, large meals or high-fat foods close to the time you take the medication can delay the onset of effects.
  • The tablet should be taken whole with some water and should not be crushed or chewed.
  • If you wake up during the night, do not take another dose as this can increase the likelihood of side effects.
  • The use of alcohol with this medication is not recommended as it can make the medications sedating effects much more potent.
  • Caffeine can interact with this medication (as they work in the opposite way) so drinks like coffee, tea and cola should be avoided.

Zopiclone Dosage Instructions

Just like all other sleeping tablets, zopiclone should be taken just before bedtime. The recommended zopiclone dosage is one 7.5 mg tablet at bedtime.

This sleep medicine generally takes a maximum of 1 hour to take effect and patients usually experience continuous 7 - 8 hours' sleep without any nocturnal awakenings throughout the night.

This medication is so powerful and effective at treating insomnia that doctors may only prescribe it for as little as 2 - 5 days.

After establishing a healthy sleep pattern, patients should gradually reduce their dose over a few days (up to 2 weeks) to prevent cases of rebound insomnia.

Due to its habit-forming qualities, the maximum amount of time that this particular sleep medicine should be prescribed and used for is 2 - 4 weeks.

Zopiclone Side Effects

All medications come with side effects and this one is no different, however the benefits of getting a good night's sleep for someone suffering from insomnia usually far outweighs the side effects.

This medication in particular is well tolerated by most patients, however, as with any treatment, side effects may occur in a relatively small percentage of people. These side effects will disappear when the medication has left the system, or can be easily managed.

Zopiclone side effects are most commonly experienced by patients that don't follow the dosage instructions, precautions or contraindications on the patient information leaflet.

Some Zopiclone side effects include:

  • A bitter/metallic taste in the mouth that does not go away. This side effect can, however, be alleviated by sucking on sugar-free sweets/ ice chips, sipping on water or using a mouthwash for dry mouth before bed.
  • Excessive sleepiness/tiredness. Patients should refrain from doing any concentration-based activities like driving or operating machinery until full consciousness is achieved and maintained.
  • Dizziness. This can be prevented by getting up slowly from a lying or sitting posture.

Consult with a doctor of pharmacist first if you:

  • have ever had an allergic reaction to medication.
  • are taking any other kind of medication (including herbal remedies & natural supplements).
  • have a record of drug or alcohol abuse.
  • have a mental health disorder.
  • have kidney or liver problems.
  • have myasthenia gravis.
  • are over the age of 65 years old.

Do not take this medication if you:

  • are pregnant, trying to get pregnant, or breastfeeding.
  • have breathing problems such as sleep apnoea.
  • have already consumed alcohol or other recreational drugs such as cannabis.
  • are under the age of 18 years old.

Note: This is not a complete list. For a full list of side effects and precautions a patient information leaflet can be downloaded here.

Zopiclone Side Effects

Pharmacokinetics of Zopiclone

Distribution: Zopiclone is a protein-bound but this binding is weak and the blood/plasma ratio is below one. This is indicative that there is no selective uptake by red blood corpuscles. This non-benzodiazepine is distributed throughout the tissues, including that of the brain.

The highest accumulation of the active ingredients occurs in the muscles, lungs, kidneys, fat tissues and liver. In senior patients, the half-life of the medication increases by an average of 7 hours. The Plasma half-life for the average person is 5 hours. For healthy individuals, there is no observable accumulation if the dosages are within the specified amounts and once daily.

Absorption: The bioavailability of zopiclone, after oral administration is approximately 75-80%. The time to peak plasma levels is an hour or two. When you buy zopiclone online, you should note that this medication ought not to be taken after a meal of high-fat content.

A high-fat meal is not known to affect the absorption of zopiclone but reduce peak plasma levels and is thought to delay the occurrence of the main ingredient, hence delaying the onset of therapeutic effects. You should be mindful of this, and other diet requirements, when you buy zopiclone tablets online.

Metabolism: extensive metabolism of zopiclone occurs in the liver. The metabolites formed, by N-oxidation and N-demethylation, are zopiclone-N-oxide and N-desmethyl zopiclone. N-desmethyl zopiclone is an active metabolite. The hepatic enzymes which play the most significant role in the metabolism of zopiclone are CYP2E1 and CYP3A4.

Excretion: Excretion of the ingredients of zopiclone is predominantly (80%) by the kidneys and is primarily as metabolites of the medication. Race and gender are not thought to influence the pharmacokinetics of zopiclone.The elimination half-life of zopiclone (at advised doses) is approximately 5 hours.

Zopiclone UK: Did You Know?

Recent studies into internet search trends, show that in the UK each month there are over 60,000 monthly searches for the term 'zopiclone', over 6,000 monthly searches for the term 'buy zopiclone' and nearly 3,000 monthly searches for the term 'zopiclone UK'!

According to a government review (published by The Guardian), one in four adults in England are regularly being prescribed with sleeping tablets. This report also indicated that prescribing rates were higher in poorer areas, and higher for women than for men.

Recently, some manufacturers of Zopiclone UK, namely Teva and Mylan, forgot to add important safety information to the patient information leaflets, which led to millions of their zopiclone tablets being recalled to reprint leaflets.

These are just some facts we thought were interesting, for those interested in reading more about this medication there are currently over 1 million webpages indexed that contain up to date information.

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Having to not physically drive to store will also reduce the emission of gases (like carbon dioxide) which increase air pollution, thus making online shopping an eco-friendly method. A Massachusetts Institute of Technology (MIT) study in 2013 investigated the comparison of carbon footprint of online shopping to traditionally shopping. Your carbon footprint is essentially your impact on the environment.

This study took into account aspects such as haulage of goods, packaging, energy usage of computers for online purchases and the energy consumption of stores and warehouses. The results concluded that shopping online reduced the carbon footprint when compared to traditional shopping. So buy zopiclone online and help save the environment.

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In 2018, an estimated 1.8 billion shoppers purchased goods, like zopiclone, online. Worldwide e-retail sales are projected to grow to $4.8 trillion in 2021. Join millions of customers who are happy to buy zopiclone tablets online today and start reaping the benefits.

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Zopiclone Dosage
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Buy Zopiclone Online UK - No Prescription

There are many online options to choose from, with some online pharmacies even advertising 'Zopiclone 7.5 mg next day delivery UK' for people with severe cases of chronic insomnia.

Due to the large amount of orders that we process without a prescription daily we are unable to promise next day delivery, but we do promise next day dispatch and a speedy delivery (2 - 4 working days for UK orders).

We also sell all medication without the need for an online consultation or a doctor's prescription, and most patients report effective relief from the relentless symptoms of chronic insomnia with the use of this medication right from day one.

If you live in the United Kingdom of Great Britain and Northern Ireland, as well as the Republic of Ireland (and the rest of Europe) you can buy zopiclone online from our online pharmacy - prescription free.

We also have a page dedicated to Sleeping Pills, Painkillers and Anti-Anxiety Medication that you may like to look at.

If you have any question about the goods we sell, or the countries we deliver to, our customer service team is contactable by phone and email 24/7.

FAQ - Zopiclone

How does zopiclone work in the body?

Once zopiclone is absorbed into the bloodstream, it increases the activity of a neurotransmitter called GABA, which is found in the brain. Neurotransmitters are natural body chemicals, which are responsible for messages that are sent between nerve cells. GABA is a neurotransmitter and is a natural 'nerve-calming' agent. It induces sleepiness, reduces anxiety and relaxes muscles. The increased activity of GABA combats insomnia by decreasing the time a patient takes to fall asleep and reducing the number of times a patient wakes up at night. It also increases the total amount of time spent sleeping.

What is Zopiclone 7.5 mg used to treat?

Zopiclone pills are used to treat insomnia. This medication can be used to treat sleep onset insomnia, which happens when a patient has difficulty sleeping at the beginning of the night. In addition, it is effective at preventing frequent awakenings during the night so a patient can benefit from restorative sleep. Additionally, it can treat anxiety due to the sedative and calming effects it possesses.

Can it negatively affect my fertility?

Studies have shown that zopiclone does not affect fertility so this need not be a concern for users.

How long should I take this medication for best results?

Zopiclone should not be taken continuously for longer than four weeks. It can also be used on an as-needed basis.

Can I use this medication, while alcohol is also in my system?

When it comes to alcohol and sleeping tablets zopiclone is not recommended when drinking, as this combination can increase the chance of side effects.

Updated: 11th January 2021
Review Due: January 2022

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