Best Sleeping Tablet
Shopping Cart 0

How Does Pregabalin Work?

How Does Pregabalin Work?

Before we look at how this medication works, it is important to understand its background as well as its uses, safety and pharmacological effects. Questions that often get asked are what is pregabalin and how does this medication compare with gabapentin 300 mg? Both pregabalin and gabapentin are classified as gabapentinoids that work in a similar way and their pharmacological effects are much alike.

Pregabalin was developed as the successor to gabapentin and was endorsed for medical use in 2004. It is also known by the brand name Lyrica and became the first medication approved for the treatment of fibromyalgia in 2007. In clinical studies, this medication has also been shown to be highly effective in the treatment of nerve pain and generalised anxiety disorder.

There is no evidence to suggest this treatment has any persisting negative effects, even when taken for years, so long-term use is generally considered safe. It works by altering the way in which nerves transmit pain signals to the brain. As a result, it reduces the intensity of nerve pain, making conditions like diabetic peripheral neuropathy and postherpetic neuralgia more manageable.

What is Pregabalin?

How Long Does It Take for Pregabalin to Work?

The length of time it takes for this painkiller to work varies from one person to another. Most people will start feeling an improvement in pain within 1 to 2 weeks. However, for some people the effects may be felt straight away and for others it may take slightly longer than two weeks. The following are pregabalin dosage guidelines for different kinds of pain:

  • For treating diabetic neuropathy (nerve pain caused by diabetes), the adult dosage is 50 mg which can be taken 3 times daily. You can increase or reduce your dosage based on how well you respond to treatment. However, 100 mg is the maximum dosage, which can be taken in 3 divided doses, to a maximum of 300 mg throughout the day. For senior patients (people over the age of 65), you should take this medication normally unless you have problems with kidney function.
  • For treating shingles (nerve pain due to herpes zoster), the adult dosage is 75 mg to 150 mg which can be taken twice a day. You may prefer a dosage of 50 mg to 100 mg, which can be taken three times daily (not exceeding 300 mg per day).

You can increase your dosage depending on how the medication reacts to your body. The maximum dosage for this medication is 300 mg which can be taken twice a day, or 200 mg which can be taken 3 times daily (not exceeding 600 mg per day).

  • For spinal cord injuries/pain, the adult dosage is 75 mg to 150 mg that can be taken twice a day. You can increase your dosage within a week to 300mg per day, divided in two doses (12 hours apart).

For optimal treatment outcomes, it is best to try and take this medication at the same time each day. If you forget to take a pregabalin dose, take it as soon as you remember unless it is almost time for the next dose.

How does Pregabalin work

How Long Does Pregabalin Last?

On average, pregabalin 300 mg tablets last 10 to 12 hours in the body but this medication usually needs a few weeks to become entirely effective. A clinical trial was conducted to assess the efficacy and time to onset of effects of this medication. Altogether, 338 patients with diabetic peripheral neuropathy or postherpetic neuralgia were involved in the study. They were given doses of up to 600 mg of pregabalin per day and the researchers used a numerical pain rating scale to determine results. It consisted of a rating of 1 to 10, whereby 1 represented no pain and 10 the worst pain imaginable.

By the end of day 1, they benefited from a decrease of 1 point on the pain rating scale. At the end of day 13, the pain rating had decreased by two full points and by day 23, it had decreased by 3 full points. The study confirmed the efficacy of this medicine and that it has a rapid onset of effects.

Pregabalin Dosage

How Well Does Pregabalin Work?

In clinical research, this medication has been known to work well as a treatment for pain and has even been shown to work well as a mood stabiliser. It can also help improve sleep and has assisted people with fibromyalgia in terms of getting back to their normal daily routines. Everyday Health has compiled a review of patient experiences and overall, ratings are positive, particularly for neuropathic pain and generalised anxiety disorder.

How Long Does Pregabalin Stay In Your System?

This medication has a half-life of about 5 to 7 hours so it takes this amount of time to eliminate half the medication from the body. Your body will process this medication quickly and it may stay in your system for about 33 hours. This length of time can vary, however, and it is dependent on a variety of individual factors that include the following:

  • The age of a person
  • A person's weight
  • Metabolism
  • Liver and kidney function
  • Liver and kidney function
  • Dosage level and frequency of use
Pregabalin Side Effects

When taken at higher doses, the likelihood of pregabalin side effects increases so the lowest effective dose should be administered during treatment. Overall, the following side effects tend to happen in slightly more than 10% of people:

  • Dizziness
  • Drowsiness
  • Headache
  • Nausea

Dizziness and drowsiness can be managed by ensuring that you do not increase the dose too quickly during treatment. This side effect generally wears off within the first two weeks of taking this medication. If you experience a headache, make sure you get plenty of rest and drink enough fluids to prevent a headache caused by dehydration. The use of alcohol and caffeine should be limited or avoided during treatment. Nausea can be prevented by taking this medication with food.

Looking to buy pregabalin for pain? If you are looking to buy painkillers in the UK, you can place an order online today. Ordering medication online from us is easy, safe and secure. Once we have received your order, you will be sent an email confirmation and the medication is dispatched within 24 hours. Medications usually take 2-4 business days to arrive at the customer's address.

Buy pregabalin in the UK safely and securely and treat pain or anxiety with an effective medication. As well as the strongest painkillers on the market, we also sell a wide range of strong sleeping pills and anxiety medication at without a prescription! If you have any questions, please contact us for an informative reply. We look forward to helping you with a pain relief option.




Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for

Phil Muston – May 16, 2021
Hi Sarah, I suffer from nerve pain which has in turn led to mental health issues during lockdown. I was previously having difficulties getting my medication but knowing that I can purchase it safely from the comfort of my home has been a huge tonic and I wanted to thank you. Phil Muston

Post Comment

Your email address will not be published.
Required fields are marked *

Rate this article