A common question associated with this sleep aid and still being asked, is: What is nitrazepam? Also known by the brand name Mogadon, this medication belongs to the benzodiazepine group. It has sedative, anxiolytic and muscle relaxant properties. It generally slows down the body's functions, making it useful in the treatment of anxiety and insomnia.
These tablets should be taken immediately before bedtime. You should make sure that you will be able to have at least 7 to 8 hours of undisturbed sleep. This will ensure that you benefit from efficient sleep, which is typically characterised by slow wave sleep (SWS), also commonly known as deep sleep. This usually results in a feeling of being well-rested in the morning with sufficient energy levels for the day.
This medication can be taken on a full or empty stomach. However, taking it with food can affect the onset of effects. A controlled trial took place to assess the different effects that light food would have on the pharmacokinetics and pharmacodynamics of this medication. The pharmacokinetics of a medication refers to how it is absorbed, distributed, metabolised and eliminated from the body. The pharmacodynamics, on the other hand, refers to what the medication does to the body, such as receptor binding and chemical interactions.
In the study, two other benzodiazepines were also tested and 21 patients were involved. The participants were randomly assigned to three groups for each medication and 7 patients received nitrazepam sleeping tablets. On separate occasions, each patient took a single dose of their treatments after light food or after fasting overnight. Various assessments were used to determine results including blood samples, reaction time of patients and visual analogue scales.
The results showed that light food delayed the time it took for this medication to reach maximum concentrations in the bloodstream by about 1 hour. These results confirmed that although nitrazepam can be taken with or without food, the effects may be delayed slightly if it is taken with food.
The recommended dosage for nitrazepam generally depends on the severity of your condition, how you respond to the medication, your age and body weight. You may not need to take this medication every night and it can be used on an as-needed basis. Treatment generally should not last longer than four weeks if this medication is taken on consecutive nights.
The following are the usual nitrazepam dosage guidelines for the treatment of insomnia:
This medication should be taken whole with some water or another non-alcoholic drink. If you forget to take a dose, do not take an extra dose to compensate for a missed dose.
Another frequently asked question associated with this medication is, how does nitrazepam work?
Once ingested, this medication is rapidly absorbed in the body and reaches its peak concentrations in the bloodstream within about 2 hours. It works by binding to certain receptors in the brain known as GABA receptors. As a result, this medication enhances the activity of gamma-aminobutyric acid (GABA). GABA is a neurotransmitter that transmits messages between nerve cells. It acts as a calming messenger which helps control feelings of nervousness and anxiety, particularly when nerve cells in the brain become overactive. Patients with insomnia typically have unusually low levels of GABA. By enhancing GABA levels, this medication helps reduce anxiety, relax muscles and induce restful sleep. After taking a tablet, a person with sleeping difficulties is usually able to fall asleep more easily and stay asleep throughout the night.
Some medications may interact with nitrazepam tablets. The following table displays medications that should be avoided or used with extra caution when taking this medication for insomnia:
| Type of medication | Examples of these medications |
| Sleeping tablets, tranquilisers and sedatives | Zopiclone, zolpidem, diazepam and lorazepam |
| Anti-anxiety medication and medications for depression | Monoamine oxidase inhibitors (MAOIs) such as phenelzine and tranylcypromine and selective serotonin reuptake inhibitors like paroxetine and sertraline. |
| Antihistamines | Medications that are used to treat allergies and cause drowsiness. These medications include chlorphenamine and clemastine. |
| Painkiller medication | Strong painkillers such as opioid analgesics. |
| Muscle relaxants | These medications include metaxalone, cyclobenzaprine and tizanidine. |
This medication is available in two strengths, namely, nitrazepam 5 mg and nitrazepam 10 mg tablets. The dosage should be individualised for each patient and clinicians often recommend taking this medication on an intermittent basis. Always take the lowest effective nitrazepam dosage as this will reduce the likelihood of nitrazepam side effects. This medication is highly effective at relieving feelings of nervousness tension and anxiety. Although insomnia has a several causes, it is often caused by anxiety. In fact, anxiety and insomnia tend to intertwine and the one condition can make the other worse. This can lead to an unhealthy cycle characterised by patterns of poor sleep.
The upside is that insomnia is treatable and this medication can help break patterns of unrestful sleep. The dose can be adjusted according to the severity of your anxiety and sleep deprivation. This medication can help re-establish a consistent sleep schedule so the daytime drawbacks of insomnia such as fatigue and drowsiness can prevented.
It is unsafe to consume alcohol with this medication. Alcohol tends to increase the sedative effects, which can make you feel excessively sleepy. Both benzodiazepines and alcohol are central nervous system depressants so taking them together can increase the risk of side effects. You can buy sleeping pills from established online pharmacies and regain a healthy sleep schedule. Using alcohol to relax and induce sleep often leads to reduced sleep quality and sleep deprivation. It also tends to interrupt sleep during the night, so it is advisable to rather use an effective, approved medication.
If you are struggling with sleepless nights, you can buy nitrazepam pills here, and take this medication as advised to safely treat insomnia.
Don't forget, at www.bestsleepingtablets.com, as well as strong sleeping pills, you can also buy a wide selection of anxiety medication and painkillers without a doctor's prescription!
CONTENT CHECKED: 09th AUG 2022
NEXT CHECK DUE: AUG 2023
Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for https://www.bestsleepingtablets.com/.
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