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Tramadol Side Effects

Tramadol Side Effects

The NCI (National Cancer Institute) defines an adverse effect as 'an unexpected medical problem that happens during treatment with a drug or other therapy.' These effects are not biased to any one treatment as all medicinal solutions come with the risk of side effects. Side effects are often divided into five categories. Tramadol side effects are no different and are categorised in the very same way.

Below is a detailed look at the individual side effects linked to the painkiller and their prevalence:

Side effect Prevalence Expression Tramadol side effects
Common (frequent) In between 1 in 10 and 1 in 100 users experience them Mild Dizziness and vertigo, nausea, constipation, headache, drowsiness, vomiting, itchiness, weakness, sweating, heartburn, dry mouth, diarrhea
Uncommon (infrequent) between 1 in 100 and 1 in 1,000 users experience them Mild Whole-body discomfort, rash, hives, mild breathing difficulty, sore throat, congestion, confusion, coordination issues
Rare 1 in 1,000 and 1 in 10,000 users experience them Severe Respiratory depression, serotonin syndrome, heart rhythm problems called QT prolongation, urine retention or frequent urination, allergic reactions

These side effects typically occur because of:

  • An individual reaction or allergy to a specific ingredient in the treatment
  • A negative domino effect where the pill is used to treat a condition but also negatively affects healthy cells in the process
  • Dosage issues: the dosage can either be too high or low and may need adjustments
  • Interactions between different medicines that are being taken concomitantly

Patients must remember that these side effects do not occur with every use of the tablet, in fact, they sometimes may not occur at all. Thus, patients should not be deterred from using the tablet and should instead be encouraged to find out more about the tablet. This can be done by asking common question such as, what is tramadol? Additionally, more information can be found on patient information leaflets.

Tramadol Effects

Tramadol Effects

When patients buy painkillers in the UK, they will find that most online pharmacies advocate for the analgesic effects of tramadol, thereby encouraging patients to choose the treatment over other options. This is because the tablet has a well-balanced profile that is patient-centric. The analgesic effects of tramadol are almost completely due to its mechanism of action, which is why most patients ask how does tramadol work? In essence, the painkiller works by simultaneously affecting the body and the mind to bring about a feeling of subsided pain or pain relief.

Once absorbed into the bloodstream, the medication acts on pain receptors, found in the central nervous system (CNS) and the brain, to block the sensation of pain. It can also affect a patient's emotional responses to pain as it stops the way in which a patient may perceive, receive and feel pain. This MOA allows it to have a more profound pain-relieving effect on the body, which helps patients effectively manage, control and treat pain as well. In addition to these effects, the treatment also produces the following effects:

  • Euphoria and anxiolytic effects - As mentioned above, the tablet affects the user's emotional response. This MOA is similar to antidepressants in that it enhances serotonin and norepinephrine levels in the brain. This may lead to elevated moods, euphoria, relaxation, calmness and a general sense of well-being too. Some individuals find that these pleasant symptoms reinforce the analgesic effects brought about by the tablet.
Is Tramadol Dangerous?

Is Tramadol Dangerous?

  • All medicinal treatments come with a fair amount of risk. There are quite a few components that might deter consumers from pharmaceutical use, and these can range from mild side effects to slightly more complicated reactions. Each tramadol dosage comes with similar risks and thus, most consumers may consider the tablet dangerous.
  • However, patients should remember this vital point: the FDA only approves a treatment if the expected benefits outweigh the known risks. When this painkiller was first approved in 1995, consumers labelled it dangerous due to its classification as an opioid.
  • They often linked the downsides of opioids to tramadol painkillers. However, this notion is severely misguided as the tablet does have opioid risks related to it. This is because the medicine is a synthetically based opioid and not a natural one.
  • This reduces a lot of the opioid-based risks, like tolerance, dependence, addiction and more. Nevertheless, the tablet is still tightly regulated as unwarranted usage can cause dangerous adverse effects. Essentially, the tablet is a safe and effective choice for patients who genuinely require the use of its analgesic effects.
Tramadol Addiction

Tramadol Addiction

Patients, who buy tramadol in the UK and various other parts of the world, may often not be concerned about addiction when using this tablet, because several safety studies are linked to it. While the tablet is considered one of the least potent opioid treatments in its class, addiction is still possible if misused. Continued use of the tablet can lead to patients developing an increased level of tolerance, thus making the treatment less effective. This will result in higher doses being consumed and subsequent addiction, as well as certain tramadol side effects, being developed.

It is, therefore, important to be aware of addiction warning signs, such as:

  • Nausea
  • Constipation
  • Drowsiness
  • Confusion
  • Poor coordination
  • Feeling high (euphoria)
  • Slowed breathing rate
  • Continuously increasing doses
  • Hyperalgesia (increased sensitivity to pain with higher doses)
Tramadol Withdrawal Symptoms

Tramadol Withdrawal Symptoms

When you use tramadol for pain, the therapeutic manages and controls the sensation of pain in the same way an opioid would. Patients often assume that because this treatment works like an opioid, other opioid-related aspects, such as withdrawal symptoms, are linked to it as well; however, this is incorrect.

Unlike traditional opioids, the tramadol painkiller affects several neurotransmitters in the brain, including serotonin. Due to this effect, patients may experience withdrawal symptoms that commonly associate with antidepressants rather than opioids. Patients going through withdrawal often start experiencing symptoms that are similar to tramadol side effects, before experiencing the following:

  • Diarrhea
  • Gooseflesh
  • Psychosis
  • Agitation
  • Upset tummy
  • Sweats or chills
  • Trouble sleeping
  • Loss of appetite
  • Nausea or vomiting

Patients will experience at least 2 to 3 of the symptoms mentioned above. They typically occur a day or two after the last prescribed dose was taken. The effects of tramadol 50 mg on opioid receptors in the brain are comparatively mild, which means that it will be relatively easier for the brain to adjust to the absence of the compound. Thus, withdrawal episodes can possibly resolve in approximately a week or so.

As well as the strongest painkillers on the market, we also sell a wide range of strong sleeping pills and anxiety medication at without a prescription! If you have any questions, please contact us for an informative reply. We look forward to helping you with a pain relief option.




Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for

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