In 1955, the chemist Leo Sternbach, of Hoffmann-La Roche, identified the first benzodiazepine. This benzodiazepine was chlordiazepoxide (Librium) and was marketed by Hoffmann-La Roche by 1960. Diazepam, which is a benzodiazepine similar to that of nitrazepam, was then introduced to the pharmaceutical industry as the brand, Valium in 1963.
Nitrazepam was patented in 1961 and then approved for medical use (as sleeping tablets) in 1965. Back then it was not possible to buy nitrazepam online yet the popularity of the medication still grew significantly. This is in part due to the efficacy of benzodiazepines. Nowadays the internet is an important healthcare tool in the sale and proper usage of medication. However, the misuse of benzodiazepines is still possible, which is why research is recommended before you buy nitrazepam.
The percentage of adults recorded to have been prescribed a benzodiazepine, in the United States (U.S), has risen by 30% from 1996 to 2013; and UK studies have revealed proportionately similar results. There is significant evidence that benzodiazepines are safer and more effective than their predecessors, barbiturates. It is now more convenient than ever to buy nitrazepam online through pharmacies dedicated to providing safe medications and hassle-free shopping.
While the loss of a loved one, a divorce, moving house and a diagnosis of terminal illness rate among the highest causes of stress and anxiety, lack of sleep comes in at a close second. None of us cope too well after missing out on sleep deprivation. This is hardly surprising since a lack of sleep affects your mind and your body profoundly. To get the sleep you need you can buy nitrazepam.
Not getting enough sleep has such an adverse effect on the brain that you may become a danger to yourself and others, albeit unwittingly. You may find that no matter how hard you try you cannot think properly and it may feel as if your brain is swathed in spider webs. You may find that you move slower and do not have much energy but this can be helped if you take nitrazepam tablets.
If you do not usually take pills because you worry about dependency issues it is important to note that nitrazepam 10 mg is not intended for long-term use: once you have re-established your natural sleeping pattern you can stop taking the medication.
Benzodiazepines are a class of medication which are chemically synthesised by the fusion of a benzene ring and a diazepine ring. These are psychoactive chemicals which mean they are substances that alter the functioning of the central nervous system (CNS).
This action has an effect on mood, perception, behaviour or cognition. Benzodiazepines, like nitrazepam, enhance the neurotransmitter gamma-aminobutyric acid (GABA). They presumably exert their effects by binding at stereo specific receptors, specifically the GABAA receptor. The mechanism of action of benzodiazepines makes this class of medicine useful as:
Nitrazepam works by affecting the transmission of chemical messages through neurotransmitters. This has a calming effect on the mind which promotes better sleep patterns in those experiencing sleep difficulties.
A clinical study involving the administration of nitrazepam and temazepam, conducted by Priest and Rizvi (1976), reported that patients given 5 mg nitrazepam - as opposed to 10 mg temazepam - experienced less impairment and were more clear-headed in the morning following the trial study.
It was also found that nitrazepam was useful for the trial patients to sleep longer and awaken later, over the 24-hour test period. This comparative trial further reported that nitrazepam showed no toxicity over the 434 patient days of administration.
As with most benzodiazepines, there are precautions to take note of before you buy nitrazepam.
Harmful effects in children: nitrazepam tablets are not recommended for those under the age of 18. There is evidence, however, of this medication being useful for the treatment of epilepsy in children.
The anti-convulsant properties of Mogadon, a medication with nitrazepam as the active ingredient, were studied in 31 paediatric trial patients with varying seizure patterns (Jan et. al., 1971). The study found that eleven of 15 patients showed an improvement of the symptoms of minor motor seizures. The remaining test patients were recorded as obtaining complete relief. Children in the clinical trial with miscellaneous seizures showed improvements with varying extents.
Furthermore, the side effects observed were reported to be mild and transient. The epilepsy study concluded that nitrazepam was relatively safe and effective for minor motor seizures, particularly infantile spasms. Administration of this benzodiazepine in children should be done so with supervision.
Impairment in seniors: the therapeutic benefits of this medication are significant in all age groups, including the elderly. However, administration of nitrazepam in geriatrics should be preceded with caution. There are increased impairments in balance and steadiness in this age group due to heightened adverse effects.
Seniors are more likely to experience cognitive deficits as the ageing brain is more sensitive to nitrazepam. This sleep aid is extensively metabolised in the body and the side effects may be due to a slower clearance of the medication from the body of older individuals. The elimination half-life in younger adults is 29 hours, in contrast to the 40 hours in senior patients.
Detrimental effects in developing foetuses: Using nitrazepam for sleep and anxiety when pregnant can cause neonatal withdrawal syndrome. Benzodiazepines are lipophilic and can therefore penetrate membranes. This is significant as penetration of the placenta can result in significant uptake of the active ingredient. Nitrazepam should only be used in situations where the benefits of the medications outweigh the risks.
Caution in hypotension and hyperthyroidism: Hypotension is a medical term used to describe low blood pressure. Using nitrazepam can further these levels and so caution should be exercised in these circumstances. For conditions, like hyperthyroidism, a delay in the metabolism of the nitrazepam is probable and this can lead to an accumulation of the medication in the body. These and other special precautions can be found on the manufacturer's packaging when you buy nitrazepam online.
Nitrazepam tablets are most commonly used as sleep aids and are useful for inducing a relaxing and calming effect on a busy mind. Nitrazepam 10 mg tablets should be taken at the same time every day and can be administered with or without food. A proper routine with regard to the administration of the medication is important as it maintains a consistent measure of the main ingredient in the body.
A full course of the medicine ought to be completed to optimise the therapeutic benefits, but nitrazepam is not recommended for use in the long-term. A missed dose of nitrazepam should also be taken as soon possible provided that the missed dose is not within a few hours of the next scheduled dosage.
When you buy nitrazepam for use as a sleep aid, the medication should be taken 30 to 40 minutes prior to retiring to bed and only when there are at least 7 hours available to dedicate to sleep. Nitrazepam should be used exactly as advised for optimal benefits.
It is unbelievable to imagine a world where you cannot shop online because it has become so popular, particularly amid the Corona virus. You waste much less time shopping online as opposed to walking from shop to shop trying to source the exact item you need. Shopping online allows you to refine your search and to enter sites that only contain the item you are searching for.
If you wish to buy nitrazepam you can easily search online for the online pharmacies near you and decide which one offers the best deals in terms of service, delivery, prices and benefits.
Since Bitcoin is a self-governing and self-regulating financial network, you do not pay sales tax fees when you pay for goods or services with your Bitcoins. In addition, you pay a fraction of the transaction costs charged by the banks when you use your Bitcoin account to make payments.
Nitrazepam is readily available at unbelievably affordable prices from our well-established online pharmacy hassle free and where we deliver to you directly. We also stock a wide range of other sleeping pills and painkillers to help you get a good night's sleep.
Updated by Admin: 13 January 2021
CONTENT CHECKED: 09th AUG 2022
NEXT CHECK DUE: AUG 2023
Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for https://www.bestsleepingtablets.com/.
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