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What is Pregabalin?

What is Pregabalin?

Pregabalin, also marketed under the brand name Lyrica among others, belongs to a class of medications known as anticonvulsants. This medication is used to reduce or prevent seizures and it can be used alone or in combination with other medications. It has anti-anxiety and pain-relieving effects that make it useful in the treatment of anxiety disorders and various conditions that cause pain.

Pregabalin for Pain Relief

Neuropathic pain, also known as nerve pain, is caused by damaged nerves. People with postherpetic neuralgia (PHN) or diabetes are more prone to this type of pain, which can occur in the fingers, toes, feet, hands, and arms. It can be described as a shooting, burning or prickling sensation that may happen all the time or it may occur sporadically. In a similar way, it can range in severity from being mild and continuous to intense and debilitating. It tends to be worse when an individual is resting and this may result in sleeping difficulties, thereby reducing a person's quality of life.

The upside is that nerve pain is treatable and pregabalin has been shown to significantly alleviate neuropathic pain. Pregabalin painkiller tablets are also used in the treatment of fibromyalgia. This condition causes muscle stiffness, pain, tiredness as well as trouble falling and staying asleep at night. Research suggests that pregabalin reduces the number of nerve signals in the nervous system and subsequently relaxes oversensitive nerve cells.

What is Pregabalin?

Pregabalin Active Ingredient

Pregabalin tablets come in 75 mg, 100 mg, 200 mg, 225 mg and 300 mg doses. They also contain the following inactive ingredients: gelatin, colloidal anhydrous silica, titanium dioxide, maize starch and lactose. The active ingredient was developed as the successor to gabapentin, which is a similar medication that is mainly used to treat partial seizures and neuropathic pain.

What is Pregabalin Used For?

Besides neuropathic pain and fibromyalgia, this medication is also approved by the FDA for the treatment of generalised anxiety disorder. In addition, it is often recommended off-label for the treatment of various other conditions, which include:

  • Social anxiety disorder
  • Bipolar disorder
  • Insomnia
  • Restless legs syndrome
  • Chronic pain
How does Pregabalin work

Patients still ask how does pregabalin work to actually treat these various health issues? This medication is generally known to work in the following ways:

  • For seizures, it reduces unusual electrical activity in the brain and this is believed to stop seizures.
  • With neuropathic pain, it is believed to mitigate pain by disrupting pain signals that travel through the nervous system.
  • For anxiety relief, it is believed to prevent the brain from activating the release of anxiety-inducing chemicals such as glutamate.

In general, the dosage will be individualised for each patient and the condition being treated. The guidelines for treating diabetic peripheral neuropathy (nerve pain caused by diabetes) are as follows:

  • Adult dosage: 50 mg that can be taken 3 times daily. You can increase or reduce your dosage based on how your body reacts to the medication. However, 100 mg is the maximum dosage that can be taken in 3 divided doses, to a maximum of 300 mg throughout the day.
  • Senior dosage (people over the age of 65): persons in this age group as well as those with liver or kidney problems may not process this medication as well as younger adults. Therefore, you will usually start treatment on a lower dosage.

The dosage guidelines for treating shingles (nerve pain due to herpes zoster) are as follows:

  • Adult dosage: 75 mg to 150 mg that can be taken twice a day. You may respond well to a dosage of 50 mg to 100 mg, taken three times daily (not exceeding 300 mg per day). You can increase your dosage depending on how the treatment reacts to your body. The maximum dosage for shingles is 300 mg which can be taken twice a day, or 200 mg which can be taken 3 times daily (not exceeding 600 mg per day).
  • Senior dosage (people over the age of 65): individuals in this age group may not metabolise this medication as effectively as younger people. As a result, the medicine may cause the body to process the tablets slower. For this reason, you may start treatment on a lower dosage.
Pregabalin Dosage

The dosage guidelines for partial onset seizures (when taken in conjunction with other anti-seizure medications) are as follows:

  • Adult dosage: 75 mg taken twice daily or 50 mg, which can be taken 3 times daily (not exceeding 150 mg per day). You may increase your dose depending on how the medication reacts to your body. The maximum dosage, which should not be exceeded, is 600 mg (taken throughout the day).
  • Senior dosage (people over the age of 65): if you are in this age group and have problems with your kidneys, you may need to start treatment on a lower dosage. The reason for this is that patients with kidney problems tend to metabolise this medication at a slower rate.

The pregabalin dose for fibromyalgia is as follows:

  • Adult dosage: 75 mg to be taken twice daily. You may adjust your dosage depending on how you react to the medication; however, the maximum dosage is 450 mg (throughout the day).
  • Senior dosage (ages 65 years and older): a lower dosage regimen is usually recommended for elderly patients with fibromyalgia, particularly at the beginning of treatment. The general guideline is to start treatment at a low dose and increase it if the medication is well tolerated.

Using a lower dose during treatment can also reduce the likelihood of pregabalin side effects. Like with all medications, side effects may happen, but they do not affect every person. Some of the most common side effects are headaches, sleepiness and dizziness. These side effects typically wear off as your body becomes used to the medicine.

Pregabalin Side Effects

Where to Buy Pregabalin?

Patients who are looking to buy pregabalin 300 mg can now do so online. Our online pharmacy stocks premium-quality branded medications and the more affordable generic versions supplied by world-class manufacturers. We are dedicated to providing a safe, affordable and efficient service, which includes complete transactional security.

You can simply buy painkillers from the convenience and safety of your own home and expect a quick and discreet delivery service. As well as the strongest painkillers on the market, we also sell a wide range of strong sleeping pills and anxiety medication at without a prescription! If you have any questions, please contact us for an informative reply. We look forward to helping you with a pain relief option.




Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for

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