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How Does Zolpidem Work?

How Does Zolpidem Work?
  • People with insomnia often have atypical questions, such as what is zolpidem and how does it work? If you are in this boat, you will be glad to know that zolpidem is in essence a highly effective pharmaceutical, which assists in the treatment of sleep disorders by causing a depression of the central nervous system (CNS).
  • These tablets work by boosting a chemical in your brain, which is called gamma-aminobutyric acid or GABA, and ultimately leads to improved sleep conditions. The chemical GABA blocks some of the neurotransmitters that send messages in the brain, and it is through this inhibitory effect that feelings of calmness and relaxation can be acquired.
  • A zolpidem dosage is typically well-tolerated by patients (causes minimal zolpidem side effects) as these therapeutics are classified as ‘Z-drugs', that is, medicines categorised as non-benzodiazepines.
  • Non-benzodiazepines are different from benzodiazepines on a molecular level but function in a similar manner. Additionally, they are normally regarded as safer than psychoactive medicines.
What is Zolpidem?

How Long Does It Take for Zolpidem to Work?

  • These tablets usually take around 1 hour to start working. This is known as the onset of action and is defined by the duration of time a medicine takes to bring its therapeutic effects to prominence.
  • The onset of action is an important factor relating to the administration of medications as it provides vital information about a therapeutic. This information can include when the tablets should be taken as well as how often they may be administered.
  • For example, if a sleep medicine, such as zolpidem, takes an hour to take effect, this hypnotic should ideally be administered an hour to two hours prior to retiring to bed. This will give the medicine sufficient time to work and ensure you experience the therapeutic effects at the time when they are most required.
  • The onset of action is not a precise indication of when a medication will take effect and can be altered by certain factors, such as:
  • Foods and drinks: a meal, such as one which has high-fat content, can delay the onset of action of a medicine. This is because these sorts of meals can prolong gastric emptying (the process by which the stomach contents are removed).
  • Body chemistry: how quickly your body breaks down medications and absorbs them is a factor which can influence the onset of action of a therapeutic. People with slower metabolisms may take longer to process medications and therefore experience the therapeutic benefits later than others.
  • Gender: women tend to experience the effects of medications much quicker than men. This can be due to their lower body weights as well as other factors.
How Zolpidem Tablets Work

How Long Does Zolpidem Last?

  • Zolpidem will normally make you feel drowsy and sleepy, after taking it. Effects may differ from person to person as a medication can affect a person in different ways. Some people are prone to feeling sleepier than others, even well after taking the medication (next day residual effects).
  • Some people, during the first few days of taking zolpidem tartrate, may also feel sleepy during the daytime. This will require one to be extra wary and vigilant as these effects can affect your ability to carry out day-to-day tasks.
  • Ambien sleeping pills usually have a half-life of about 2 hours. Half-life refers to how long it takes half of the medication to leave the body. Surprisingly, this is relatively shorter than most sedative medicines. Ambien withdrawal symptoms generally manifest themselves within 48 hours of the last administered dose. For many people, symptoms on the first or second days of treatment can typically be mild but these effects can increase with use of the therapeutic.
Zolpidem Dosage

How Well Does Zolpidem Work?

  • This medicine offers several advantages. One of these benefits is that it activates very quickly - usually within half an hour of taking the pill. Studies have indicated that zolpidem can assist in helping patients fall asleep, with a high success rate and low residual effects. Research and scientific observations have also shown that sleep problems normally improve within 7 to 10 days of treatment with zolpidem tartrate.
  • Zolpidem will not affect your contraception medication or reduce its potency. This includes emergency contraception, the combined pill and the injection too.
  • There is, however, not enough evidence to support or suggest or that taking the medicine will reduce fertility in either men or women. This area requires further study and observation. You can speak to a healthcare professional if you and your partner are trying to conceive. Your doctor may be able to review your zolpidem treatment, to incorporate family planning.

User Online Reviews (for treatment of insomnia):
Zolpidem boasts an average rating of 7.0 out of 10, from a total of 861 ratings for the treatment of insomnia (updated 3 March 2021) on most review websites. About 61% of the users who reviewed this product reported a positive therapeutic effect. On the contrary, 21% of the people who used this product reported a negative effect, a statistic that is relatively low compared to other hypnotic medicines.

Zolpidem Side Effects

How Long Does Zolpidem Stay in Your System?

  • These sleeping pills metabolise relatively fast, this means that the medication will not be detectable for very long in your system. The medication can be detected in urine for 24 to 28 hours, and for approximately 6 to 20 hours in the blood. These time frames may be increased when using higher dosages.
  • Zolpidem 10 mg, as a treatment for sleep problems, should only be used in the short-term (up to a maximum of 4 weeks). The reason for this is because your body can become addicted or dependent on the active ingredient in the medicine.
  • Should you feel the need to take these tablets for longer than 4 weeks, consult your doctor as a specialist will be able to advise you and perhaps recommend other alternative dosing schedules to help you deal with the sleep deficiency.

You can buy zolpidem in the UK easily and conveniently through e-commerce platforms, namely online pharmacies. However, it is vital that you make use of credible sites, such as ours. Once again, it is important to remember that in order to buy sleeping tablets as a patient you need to follow the recommended usage and dosage guidelines.

Don't forget, at, as well as strong sleeping pills, you can also buy a wide selection of anxiety medication and painkillers without a doctor's prescription!




Quickly establishing herself as a content writer Sarah found herself drawn to the medical industry – specifically in the field of Cognitive Behavioural Therapy (CBT-I), and sleep aids for insomnia. Sarah brings a wealth of experience, expertise and enthusiasm and will no doubt keep our readers absorbed with her insightful and thoughtful blogs written especially for

Jay Blake – May 13, 2021
Great post Sarah I have been greatly impressed by your level of knowledge and found your article most helpful. Thank you Jay Blake

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